Since 2020 is over, people worldwide finally feel that a comprehensive global vaccination plan can control covid-19 spread. Nevertheless, here are the questions that matter the most. What significant steps should have been taken by countries’ governments to avoid this pandemic? Would it make any difference if we just brought some other strategies into play to control the SARS-CoV-2 as the significant concerns of health organizations in the world? What methods and plans should WHO consider as the health organization’s procedure in different countries encountering SARS-CoV-2, influenza viruses, and other novel infections?